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Tucker has contributed to more than articles in scientific journals. Her research focuses on dietary intake and risk of chronic disease, including osteoporosis, cognitive decline, obesity, metabolic syndrome, and heart disease, and on dietary methodology. She is PI of the Boston Puerto Rican Health Study, a longitudinal study on the roles and interactions of stress, social support, diet, health behavior and genetic predisposition in relation to health disparities in Puerto Rican adults. She is Editor-in Chief of Advances in Nutrition, an international review journal.
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